Association between IL2RA and juvenile idiopathic arthritis (JIA) disease severity at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study (CAPS)
نویسندگان
چکیده
Results 185 children with JIA (median age 7.2 years(IQR 3.6, 11.7), 65% female) were included. Median CHAQ score at presentation was 0.75(IQR 0.13, 1.38). There was a trend towards higher disability with increased number of copies of the rare allele of rs2104286 (Table 1) (OR 8.00 (0.93, 68.79), p = 0.06). An association was also seen between increased disability and homozygosity for the rare allele of rs11594656 (OR 3.37 (0.89–12.75), p = 0.07). There was no association with rs41295061. Conclusion Children homozygous for the rare allele (rs2104286) a SNP associated with JIA susceptibility, showed a trend towards increased disability. Interestingly, a second SNP in the IL2RA region not previously associated with JIA susceptibility also showed a similar trend. Validation of these results in larger cohorts is required. from 15th Paediatric Rheumatology European Society (PreS) Congress London, UK. 14–17 September 2008
منابع مشابه
Evidence for association of autoimmune genes with disabilty in juvenile idiopathic arthritis in a UK cohort
Methods Demographic and disease features were collected as part of CAPS at first presentation to paediatric rheumatology, 6 months, and then yearly for 3 years. SNPs were genotyped on a Sequenom MassARRAY platform. Two analyses were performed to compare the effects of the SNPs on disease severity at presentation to paediatric rheumatology clinics and then the effects over the first 3 years of J...
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